David A. Lamond joined our board of directors in 2015. Since April 2016, Mr. Lamond has served as president of En Pointe LLC, an investment firm. From 2011 to 2016, he served as the president, chief executive officer and chief investment officer of Lamond Capital Partners LLC. Mr. Lamond also is currently a member of the board of directors of Applied Molecular Transport (AMTI), a biopharmaceutical company, and previously served on the board of Arrinex, a medical device company. In addition, Mr. Lamond is on the board of directors of two non-profit organizations, Tipping Point Community and Ubuntu Pathways. Mr. Lamond holds a B.A. in History from Duke University and a J.D. from Duke Law School.
Board of Directors
Una Ryan, OBE, Ph.D. joins the board with a deep background in the biopharma space, including extensive experience serving on the boards of public, private and non-profit companies. She is currently an investor including as a managing director of Golden Seeds and as a partner in Astia Angel. Previously, she served as president and CEO of AVANT Immunotherapeutics, a company developing vaccines and Immunotherapeutics for cancer and broader health applications; Diagnostics for All; and Celldex Therapeutics. As a scientist, Dr. Ryan is credited with the localization of angiotensin converting enzyme as a target that led to the development of an important class of blood pressure medicines. In 2002 Queen Elizabeth II awarded Dr. Ryan the Order of the British Empire (OBE) for services to biotechnology. She subsequently received the Albert Einstein Award for outstanding achievement in the life sciences in 2007, as well as the Cartier Women’s Initiative Award in 2009. Dr. Ryan obtained her undergraduate degree from the University of Bristol and her Ph.D. from the University of Cambridge.
Chris Lowe has served as Cortexyme’s Chief Operating Officer since February 2021 and Chief Financial Officer since January 2019. To this role, he brings more than 25 years of leadership, operating, and financial expertise across a variety of biotech and pharmaceutical companies spanning preclinical to commercialized development stages. From June 2018 until January 2019, Mr. Lowe served as a consultant to Cortexyme and as the company’s interim Chief Financial Officer through his capacity as a partner at FLG Partners. He has also served as the Managing Partner of the Innventus Fund at Innventure since January 2017 and he has served as a partner at FLG Partners since January 2014 and its Managing Partner since January 2018. Prior to joining Cortexyme, Mr. Lowe served as the Interim Chief Executive Officer and Chief Financial Officer of Hansen Medical from February 2014 to July 2016, and he served as the Chief Business Officer and Chief Financial Officer of Anthera Pharmaceuticals from September 2007 to June 2013. He served as a director for Inspyr Therapeutics from September 2016 to December 2018, a director of EpiBiome from May 2016 to June 2018, and a director and Chairman of the Audit Committee for Asante Solutions from December 2014 to October 2015. Mr. Lowe holds a B.S. in Business Administration from California Polytechnic State University and a M.B.A. from St. Mary’s University.
Dr. Dirk Thye has served as Cortexyme’s Chief Executive Officer since May 2022. To this role, he brings more than 20 years of experience in biotechnology company creation, drug discovery, research and development, and executive leadership. Previously, Dr. Thye was Chief Executive Officer of Novosteo from September 2021 to May 2022, which was acquired by Cortexyme in May 2022. Previously, from January 2016 to July 2020, he was the Executive Chairman of Geom Therapeutics, Inc., a biopharmaceutical company, and from September 2016 to January 2018, the Chief Executive Officer of Agenovir Corporation, a biopharmaceutical company. In addition, Dr. Thye has served in varied senior leadership roles, including as Chief Executive Officer, Chief Medical Officer, and Head of Clinical Development and is a Founder of seven companies, five of which were sold with excellent returns for investors. Several of the drug development programs led by Dr. Thye achieved FDA approval and he has worked in a variety of therapeutic areas such as infectious diseases, antibody/ADC discovery, oncology, inflammation, metabolic disease, and others. His corporate financing endeavors include private, IPO, and follow-on public financings resulting in over $350 million of company investment and successful exits generating billions of dollars in shareholder value. Dr. Thye holds a M.D. from the University of California, Los Angeles and a B.A. in Molecular Biology from the University of California, Berkeley. He also completed his residency in Internal Medicine at Stanford University.
Margaret (Margi) McLoughlin, Ph.D., is an independent director. Until April of 2019, Margi worked in Pfizer’s Worldwide Business Development (WWBD) organization and Pfizer Ventures where she was a Partner in Pfizer Ventures and an Executive Director in WWBD. In this role, Margi served on the boards of 4D Molecular Therapeutics, Adapsyn, BioAtla, System1, and Cortexyme with a focus on making investments and working with companies to help advance products and technologies of value to the pharmaceutical industry. After joining Pfizer in 2001, she worked in roles of increasing responsibility in WWBD, played a significant role in defining Pfizer’s Centers for Therapeutic Innovation, in addition to leading transactions with multiple biotech companies, including Ablexis, Gliknik, and Excaliard, among others. Margi also held a position in Discovery Research at Mallinckrodt Medical developing diagnostic pharmaceuticals for nuclear medicine, MR, and X-ray imaging. After five years in the laboratory, she spent two years in Technology Planning at Mallinckrodt Medical where she supported internal R&D through outside alliances. Additionally, Margi served as Associate Director in the Office of Cooperative Research at Yale University. She received her B.S. in Chemistry from University of California, Irvine and her Ph.D. in Chemistry from University of California, Santa Barbara.
Chris Senner has nearly three decades of finance experience at industry-leading biotechnology and pharmaceutical companies. He currently serves as Executive Vice President and Chief Financial Officer of Exelixis, Inc. (EXEL), a commercially successful, oncology-focused biotech advancing medicines for difficult-to-treat cancers. At Exelixis, Mr. Senner leads a team responsible for providing the financial infrastructure for the company’s growing commercial oncology franchise, broad clinical development operations, and reinitiated drug discovery activities. Before joining Exelixis, Mr. Senner served for five years as Vice President, Corporate Finance at Gilead Sciences. Prior to Gilead, he spent eighteen years at Wyeth, including as CFO of its U.S. pharmaceuticals business and BioPharma Business Unit. Mr. Senner holds a B.S. in Finance from Bentley College.
Marwan Sabbagh, MD, FAAN | Professor of Neurology, Alzheimer's and Memory Disorders Division, Barrow Neurological Institute
Marwan Noel Sabbagh, MD, FAAN, board-certified neurologist and geriatric neurologist, hopes to work himself out of a job. Considered one of the leading experts in Alzheimer’s and dementia, Dr. Sabbagh has dedicated his career to finding a cure for Alzheimer’s and other age-related neurodegenerative diseases. He is a leading investigator for many prominent national Alzheimer’s prevention and treatment trials and is currently Professor of Neurology, Alzheimer’s and Memory Disorders Division at the Barrow Neurological Institute.
Dr. Sabbagh is on the editorial boards of the Journal of Alzheimer’s Disease and Alzheimer’s and Dementia TRCI. He also is editor in chief of Neurology and Therapy. He has authored and co-authored more than 400 medical and scientific articles on Alzheimer’s research. Dr. Sabbagh is the author of The Alzheimer’s Answer: Reduce Your Risk and Keep Your Brain Healthy, with foreword by Justice Sandra Day O’Connor, and of The Alzheimer’s Prevention Cookbook: 100 Recipes to Boost Brain Health. He edited Palliative Care for Advanced Alzheimer’s and Dementia: Guidelines and Standards for Evidence Based Care and Geriatric Neurology, published in 2014, Fighting for my Life: living in the shadow of Alzheimer’s disease, published in 2019, and his latest book titled Strong Heart, Sharp Mind was recently released in January 2022. He has been recognized with numerous awards and has been a Fellow of the American Academy of Neurology since 2004.
Dr. Sabbagh currently serves as Professor of Neurology at the Alzheimer’s and Memory Disorders Division of the Barrow Neurological Institute. Dr. Sabbagh earned his undergraduate degree from the University of California, Berkeley and his medical degree from the University of Arizona in Tucson. He received his residency training in neurology at Baylor College of Medicine, Houston, Texas, and completed his fellowship in geriatric neurology and dementia at the University of California, San Diego School of Medicine, where he served on the faculty as assistant professor. Before rejoining the faculty of the Barrow Neurological Institute, he was the Camille and Larry Ruvo Endowed Chair for Brain Health and Director of the Cleveland Clinic Lou Ruvo Center for Brain Health in Las Vegas. Prior to that, he was the director of the Banner Sun Health Research Institute in Phoenix.
Philip S. Low is the Presidential Scholar in Drug Discovery and the Ralph C. Corley Distinguished Professor of Chemistry at Purdue University. Dr. Low has spent more than 30 years exploring novel methods for targeted drug discovery, including target identification, drug design and synthesis, animal testing, and human clinical evaluation. He has published more than 500 scientific articles and has more than 360 U.S. patents and patents pending. Eight drugs stemming from his research are currently undergoing human clinical trials and seven companies (Endocyte Inc., OnTarget Laboratories Inc., Novosteo Inc., Erythrocure Inc., Umoja Biopharma Inc., Morphimmune Inc. and Eradivir Inc.) have been founded to commercialize these discoveries. Dr. Low has received an NIH MERIT Award, the ACS Award for Cancer Research (Sosnovsky Award), the AACR Award for Outstanding Chemistry in Cancer Research, both of Purdue’s awards for outstanding research (McCoy and Sigma Xi Awards), the University’s highest career achievement award (Morrill Award), the American Chemical Society’s Esselen Award and numerous other National and International awards. Dr. Low received his B.S. in Chemistry from Brigham Young University and his PhD in Biochemistry from the University of California, San Diego.
Clinical Advisory Board
Dr. Mark Brody is President and Founder of Brain Matters Research, one of the largest private clinical research facilities in the country specializing in Alzheimer’s Disease diagnosis, treatment and research. He is a nationally recognized expert in both Alzheimer’s Disease and stroke, as well as the Principal Investigator in numerous clinical trials seeking to prevent and treat Alzheimer’s. He is in private practice in Delray Beach specializing in memory disorders and stroke prevention. He is one of a small group of neurologists whose career spans an academic practice, clinical practice, as well as clinical research. A former Professor of Neurology at University of California, San Diego, and Stroke Program Director at Scipps, La Jolla, he eventually relocated to Palm Beach County in 1995. He was the founding Director of the Acute Interventional Stroke Program at Bethesda Memorial Hospital, where he and his team conducted acute stroke clinical trials seeking to optimize the “time-to-treatment” and outcomes for stroke victims.
Martin Farlow, MD | Professor Emeritus, University of Indiana & co-director of the Alzheimer’s Disease Center at Indiana University
Dr. Farlow is Professor of Neurology and Vice-Chairman of Research in the Department of Neurology at the Indiana University School of Medicine in Indianapolis. He is also Associate Co-Director of the Indiana Alzheimer’s Disease Center in Indianapolis and leads a large Alzheimer and related dementias clinical trials site in the Department of Neurology and has led and/or contributed in various ways to over 150 clinical trials over the last 25 years. Dr. Farlow received his medical degree from Indiana University School of Medicine and completed an internship in medicine and residency in neurology at the Indiana University Hospitals. Dr. Farlow is a member of many professional associations including AAN, ANA and AGS. He is also a founding member in both the American Society of Experimental Neurotherapeutics and the International Society for CNS Clinical Trials and Methodology. Dr. Farlow has lectured on the topics of aging, dementia, and Alzheimer’s disease at more than 300 meetings, conferences, and hospitals/medical schools throughout the world. He is a reviewer for numerous scientific journals and on the editorial boards of MedLink and Current Alzheimer Research.
David Munoz, MD | Head of Pathology at St. Michael’s Hospital, Toronto, and Professor at University of Toronto
Dr. David Munoz holds an MD from Navarre and MSc in Pathology from Queen’s University, Ontario. He trained in neurology and neuropathology and became a Fellow of the Royal College of Physicians and Surgeons of Canada in 1984. He has practiced in Vermont, Saskatoon, London (ON), Madrid, and Toronto, and briefly in Vancouver. He is currently a Neuropathologist and Head, Division of Pathology at St. Michael’s Hospital, Toronto, and Professor, Department of Laboratory Medicine and Pathobiology, University of Toronto. He is the author of 194 peer-reviewed papers, 20 book chapters, and co-author of one book. He has held research grants in Canada (Medical Research Council and Canadian Institutes of Health Reasearch) and USA (National Institutes of Health). His research interest is focused on neuropathology, particularly the mechanisms of development and progression of degenerative diseases of the brain, including Alzheimer’s disease, the non-Alzheimer dementias, movement disorders, and amyotrophic lateral sclerosis. His other research interest in neurooncology is derived from his clinical practice.
Marwan Sabbagh, MD | Professor of Neurology, Alzheimer's and Memory Disorders Division, Barrow Neurological Institute
Marwan Noel Sabbagh, MD, board certified neurologist and geriatric neurologist, is considered one of the leading experts in Alzheimer’s and dementia. He is Professor of Neurology at the Alzheimer’s and Memory Disorders Division of the Barrow Neurological Institute at Dignity Health/St Joseph’s Hospital and Medical Center in Phoenix, Arizona. Dr. Sabbagh has dedicated his career to finding a cure for Alzheimer’s and other age-related neurodegenerative diseases. He is a leading investigator for many prominent national Alzheimer’s prevention and treatment trials. Dr. Sabbagh is on the editorial board for Journal of Alzheimer’s Disease and BMC Neurology. He is now editor in chief of Neurology and Therapy. He has authored and co-authored almost 370 medical and scientific articles on Alzheimer’s research. Dr. Sabbagh is the author of The Alzheimer’s Answer: Reduce Your Risk and Keep Your Brain Healthy, with foreword by Justice Sandra Day O’Connor, and of The Alzheimer’s Prevention Cookbook: 100 Recipes to Boost Brain Health. He has edited Palliative Care for Advanced Alzheimer’s and Dementia: Guidelines and Standards for Evidence Based Care and Geriatric Neurology, published in 2014 and Fighting for my Life: living in the shadow of Alzheimer’s disease in 2019. Dr. Sabbagh has been recognized with numerous awards, including WestMarc Innovator Award, 2015; Fellow of the American Academy of Neurology, 2004. He earned his undergraduate degree from the University of California, Berkeley and his medical degree from the University of Arizona in Tucson. He received his residency training in neurology at Baylor College of Medicine, Houston, Texas, and completed his fellowship in geriatric neurology and dementia at the University of California, San Diego School of Medicine, where he served on the faculty as assistant professor. Prior to his current position, Dr. Sabbagh was the Camille and Larry Ruvo Endowed Chair for Brain Health and Director of Translational Research at Cleveland Clinic Lou Ruvo Center for Brain Health in Las Vegas, Nevada. Before joining the faculty of the Cleveland Clinic, he was at the Barrow Neurological Institute where he served for three years, and prior to that, he was the director of the Banner Sun Health Research Institute for 15 years.
Mercè Boada, MD, PhD | Professor, Chief Medical Officer, Fundació ACE. Barcelona Alzheimer Treatment and Research Center, Universitat International de Catalunya-Barcelona
Dr. Mercè Boada is founder and medical director of Fundació ACE, Institute Català de Nuerosciènces Aplicades. Dr. Mercè earned her PhD in Medicine from the Autonomous University of Barcelona and neurology specialist. Until 2013 she was responsible for Neurodegenerative Diseases unit at the Neurology Service, University Hospital Vall d’Hebron, Head of the research group “Alzheimer” at the Vall d’Hebron Research Institute in Barcelona Spain.
Jeffrey Cummings, MD| Emeritus of Cleveland Clinic Lou Ruvo Center for Brain Health in Las Vegas and Director of Center for Neurodegeneration and Translational Neuroscience
Dr. Jeffrey Cummings is Professor of Neurotherapeutics and Drug Development in the Neurological Institute, Cleveland Clinic; he is Director of the Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, Nevada and Cleveland, Ohio. Dr. Cummings has expertise in neuropsychiatric assessment, outcomes in clinical trials, clinical trial design and analysis and global clinical trials. He is a frequent consultant to industry. He has authored more than 500 peer-reviewed papers and 30 books on Alzheimer’s disease, neuropsychiatry, and clinical trials. Dr. Jeffrey Cummings is a member of the Alzheimer’s Disease Cooperative Study (ADCS), the NINDS Neuroprotection in Parkinson’s Disease (NET-PD) oversight committee, American College of Neuropsychopharmacology, American Society for Experimental Neurotherapeutics, American Academy of Neurology, American Neurologic Association, American Neuropsychiatric Association (past president), Behavioral Neurology Society (past president), and American Association of Geriatric Psychiatry (honorary member), among many prestigious organizations. Dr. Jeffrey Cummings graduated magna cum laude from the University of Wyoming, Laramie and obtained his MD degree (with thesis) from the University of Washington, Seattle. He completed internship at Hartford Hospital in Hartford, Connecticut and did his Neurology residency at Boston University, Boston, Massachusetts. Dr. Jeffrey Cummings had his specialty training in Behavioral Neurology at Boston University and pursued advanced studies in Neuropsychiatry and Neuropathology at the National Hospital for Nervous Diseases, Queen Square, London.
Dr. Thomas Laughren currently serves as the director of Laughren Psychopharm Consulting, LLC. He is retired as Division Director for the Division of Psychiatry Products, Center for Drug Evaluation and Research, at FDA (Silver Spring, MD). Prior to coming to FDA in September 1983, Dr. Laughren was affiliated with the VA Medical Center in Providence, RI, and was on the faculty of the Brown University Program in Medicine, also in Providence. Dr. Laughren received his medical degree from the University of Wisconsin–Madison, and he also completed residency training in psychiatry at the University of Wisconsin. Dr. Laughren is board certified in general psychiatry. As Division Director for the Division of Psychiatry Products, Dr. Laughren oversaw the review of all psychiatric drug development activities conducted under INDs and the review of all NDAs and supplements for new psychiatric drug claims. He has authored or coauthored many papers and book chapters on regulatory and methodological issues pertaining to the development of psychiatric drugs and is a frequent speaker at professional meetings on these same topics. Dr. Laughren has received numerous awards for his regulatory accomplishments.
Mark Ryder, DMD is Professor and Chair of Orofacial Sciences at the University of California, San Francisco School of Dentistry. Dr. Ryder received his DMD from Harvard School of Dental Medicine.
Lon Schneider, MD, MS is Professor of Psychiatry, Neurology, and Gerontology at the Keck School of Medicine of the University of Southern California. He is director of the California Alzheimer’s Disease Center, the Department of Psychiatry Geriatric Studies Center and co-director of the clinical core of the University of Southern California Alzheimer’s Disease Research Center (National Institutes of Health). In addition, he is principal investigator of the National Institute of Mental Health’s CATIE program, a multicenter effectiveness trial of atypical antipsychotics in Alzheimer’s disease.
Pierre N. Tariot, MD is Banner Alzheimer’s Institute director and also University of Arizona College of Medicine research professor. Dr. Tariot has investigated and lectured extensively on multiple aspects of diagnosis, therapy and prevention of Alzheimer’s disease and has published more than 350 papers on these topics. He has served as an author for several studies that have led to Food & Drug Administration (FDA) approval of treatments for Alzheimer’s disease. Dr. Tariot has led efforts to refine how behavioral changes in dementia are measured. He has contributed to large multicenter trials of a range of treatments for these neuropsychiatric features. Alongside his colleagues Dr. Tariot leads the Alzheimer’s Prevention Initiative, which is credited with helping launch a new era in Alzheimer’s prevention research. Dr. Tariot also leads the Banner Dementia Care Partners, a program designed to demonstrate the clinical and cost-effectiveness of standardized care for persons with dementia in a large health care system. He is a member of the American College of Neuropsychopharmacology.
Clive Holmes, PhD | Professor, Biological Psychiatry, University of Southampton and co-director of Memory Assessment and Research Centre, Southern Health Foundation Trust
Clive Holmes is Professor of Biological Psychiatry within Medicine at the University of Southampton with a focus on research on the biological factors that alter the clinical course of Alzheimer’s Disease and other related chronic neurodegenerative conditions but with a focus on the role of inflammation. Professor Clive Holmes was appointed to the Chair of Biological Psychiatry in 2005. He graduated with a first class honours degree in biology from the University of Sussex in 1981 and then went on to study medicine at the University of Leicester; graduating in 1987. He trained in general psychiatry at Guy’s Hospital, London with a two-year additional placement as a visiting research fellow in Neurochemistry at the Institute of Neurology, London. Following this placement, he undertook higher training as a Lecturer in Old Age Psychiatry at the Institute of Psychiatry before completing his PhD on the genetics of the neuropsychiatric features of Alzheimer’s Disease in 2001. He held a post as a Senior Lecturer in Old Age Psychiatry at the University of Southampton before being promoted to his current appointment. He is an honorary consultant in Old Age Psychiatry at Southern Health Foundation Trust.